Costunolide CAS 553-21-9

Dayang Chem (Hangzhou) Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm costunolide cas 553-21-9 hauv Suav teb, tshwj xeeb hauv kev muab cov tshuaj zoo tshaj plaws. Txais tos rau cov lag luam wholesale bulk costunolide cas 553-21-9 ua nyob rau hauv Suav teb nov thiab tau pricelist los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Khoom Taw Qhia:

1.     Specification

Qhov tseeb specifications thiab COA yuav raug xa raws li qhov kev thov.

2.     Ntim & shipping

3.     Daim ntawv thov

Costunolide, ib qho sesquiterpene lactone, nthuav tawm los tiv thaiv - mob thiab tiv thaiv - oxidant zog thiab mediates apoptosis.IC50 Tus nqi: 6.2 - 9.8 ug/mL (sarcoma cells viability) Lub Hom Phiaj: Apoptosis inducerin vitro: Costunolide ho inhibited 5}MMitsination ntau yam hauv RANKL koob tshuaj -nyob ntawm yam tsis muaj kev cuam tshuam cytotoxicity. Costunolide tsis tswj cov kev taw qhia ntxov ntawm RANKL, suav nrog cov mitogen-activated protein kinase thiab NF-B txoj hauv kev. Txawm li cas los xij, costunolide suppressed nuclear factor ntawm activated T-cells, cytoplasmic 1 (NFATc1) qhia los ntawm inhibition ntawm c-Fos transcriptional kev ua si yam tsis muaj kev cuam tshuam RANKL-induced c-Fos qhia. Cov teebmeem inhibitory ntawm costunolide tau txais kev cawmdim los ntawm overexpression of constitutively active (CA)-NFATc1 . Tawm ntawm T24 hlwb rau costunolide kuj tseem cuam tshuam nrog kev nthuav tawm ntawm Bax, down-txoj cai ntawm Bcl-2, survivin6} thiab tseem ceeb ntawm RP stream stream 2, . Ob leeg costunolide thiab dehydrocostus lactone inhibited cell viability koob- thiab lub sijhawm- nyob ntawm. IC50 qhov tseem ceeb nyob ntawm 6.2 ug / mL txog 9.8 ug / mL. Cells kho nrog costunolide tsis pom muaj kev hloov pauv hauv lub voj voog ntawm tes, me me hauv caspase 3/7 kev ua haujlwm, thiab qis qis ntawm caspase cleaved-3 tom qab 24 thiab 48 h .in vivo: Tsis yog costunolide lossis alpha-MGBL cuam tshuam cov ntshav-ethanol nce siab hauv pylorus-induced los yog traction ntawm pylorus-in vivo. Kev tswj hwm ntawm intraduodenal ethanol. Costunolide thiab alpha-MGBL suppressed gastric emptying nyob rau hauv nas muab 20% ethanol thiab 1% sodium carboxymethyl cellulose.Clinical trial:

4.     Spectrum

5.     Cov ntawv txheeb

1. Kev mob toxicity thiab genotoxicity kawm txog fermented tshuaj ntsuab formula Guibi-tang.J. Ethnopharmacol.   156 , 182-9, (2014)
2. Simultaneous quantification ntawm curdione, furanodiene thiab germacrone nyob rau hauv luav plasma siv kua chromatography-tandem loj spectrometry thiab nws daim ntawv thov mus rau ib tug pharmacokinetic txoj kev tshawb no.Biomed. Chromatogr.   29 , 1393-8, (2015)
3. Lub fluorescence siab dhau los soj ntsuam txoj hauv kev rau kev kuaj xyuas cov electrophiles reactive raws li cov tawv nqaij sensitizers.Toxicol. Appl. Pharmacol.  289 , 177-84, (2015)

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